Navjeet Kaur
Ramnarain Ruia College, India
Title: Dendrimer coated SPIONs for exploring biomedical applications
Biography
Biography: Navjeet Kaur
Abstract
Dendrimers are nano-sized, radially symmetric molecules with well defined, homogeneous mono-dispersed structure with symmetric core, an inner and outer shell. The make a suitable choice to coat SPIONs Super Paramagnetic Iron Oxide Nanoparticles (SPIONs, Fe3O4).
SPIONs were prepared by chemical co-precipitation method using microwave synthesiser which enhances the rate of synthesis and chemical reactions. The surface of these SPIONs was modified by 3-amino propyl triethoxy silane (APTES) for dendrimer coating which improves magnetic properties and size distribution. Dendrimers were synthesised using divergent method of synthesis. Polyamidoamine (PAMAM) dendrimer is coated to Fe3O4 core to prepare PAMAM-Fe3O4 core-shell nanostructures through Michael reaction. Studies show that 4th generation PAMAM dendrimers are effective phase transfer agents for SPIONs from organic media to water.
These SPIONs were characterised using suitable techniques and their biological compatibility was studied using MTT assay and simple staining techniques on Mouse fibroblast 3T3 cell line.
Such type of functionalized SPIONs can be projected for their biomedical applications. They are already being used for their magnetic properties. They are a suitable candidate for improving the contrast in MRI imaging. Surface modification of such SPIONs opens greater dimensions to their applicability in biological arenas of research.
